Premature ovarian failure - Optimize Hormones

Premature Ovarian Failure (POF)

Premature ovarian failure (POF), also known as primary ovarian insufficiency, refers to the loss of normal ovarian function before age 40. The ovaries stop producing normal levels of the hormone estrogen, which causes menopause-like symptoms such as:

• Irregular periods or no periods at all
• Hot flashes
• Vaginal dryness
• Night sweats
• Sleep problems

Causes

Doctors often don't know the exact cause of premature ovarian failure. Possible causes can include:

• Genetic factors - abnormalities on the X chromosome
• Autoimmune disease
• Cancer treatments like radiation or chemotherapy
• Infections
• Metabolic disorders like galactosemia

Diagnosis and Tests

POF is diagnosed with a blood test that measures follicle-stimulating hormone (FSH) levels. FSH levels are usually high when ovarian function drops. Doctors may also test levels of estrogen and other hormones produced by the ovaries.

Treatment

While there is no cure for premature ovarian failure, treatments can help relieve symptoms. These may include:

• Hormone therapy - Estrogen and progesterone supplements to regulate menstrual cycles and prevent complications like bone loss
• Osteoporosis medications - Bisphosphonates or denosumab to maintain bone health
• Emotional support - Counseling or support groups to cope with the diagnosis

The course of POF varies. In some cases, ovarian function may spontaneously recover. Women with POF can discuss options like donor eggs or embryos, or adoption, to help build their families.

Regular screening for complications like heart disease, osteoporosis, and autoimmune disorders is also important. Connecting with other women going through POF can help women feel supported. Finding an endocrinologist or gynecologist who specializes in reproductive issues at Optimize Hormones can optimize care.